![]() Valnegri P, Puram SV, Bonni A (2015) Regulation of dendrite morphogenesis by extrinsic cues. Puram SV, Bonni A (2013) Cell-intrinsic drivers of dendrite morphogenesis. Watanabe M, Kano M (2011) Climbing fiber synapse elimination in cerebellar Purkinje cells. Kano M, Hashimoto K (2012) Activity-dependent maturation of climbing fiber to Purkinje cell synapses during postnatal cerebellar development. Koleske AJ (2013) Molecular mechanisms of dendrite stability. Cold Spring Harb Perspect Biol 2:a001750ĭeFelipe J (2015) The dendritic spine story: an intriguing process of discovery. Grueber WB, Sagasti A (2010) Self-avoidance and tiling: mechanisms of dendrite and axon spacing. Annu Rev Neurosci 32:347–381Ĭraig AM, Banker G (1994) Neuronal polarity. Thousand-and-one-amino acid 2 kinase TrkB:īarnes AP, Polleux F (2009) Establishment of axon-dendrite polarity in developing neurons. Ras-related C4 botulinum toxin substrate 1 Ret: Myristoylated alanine-rich C-kinase substrate MEF: ![]() Α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor ASD:Ĭa 2+/calmodulin-dependent protein kinase CaMKK:Ĭa 2+/calmodulin-dependent protein kinase kinase CBP:ĬAMP-response element binding protein DSCAM:ĭown syndrome cell adhesion molecule ERK:Įxtracellular signal-regulated kinases FMRP:įragile X mental retardation protein GAP: Additionally, we briefly comment on the implications of aberrant dendritic morphology for nervous system disease. We focus on different aspects of vertebrate dendrite patterning that are particularly important in determining the neuronal function such as the shape, branching, orientation and size of the arbors as well as the development of dendritic spine protrusions that receive excitatory inputs and compartmentalize postsynaptic responses. Here, we summarize the molecular and cellular mechanisms that regulate the formation of cell type-specific dendrite patterns during development. To ensure proper neuronal function and connectivity, it is necessary that dendrite patterns are precisely controlled and coordinated with These neuron-specific morphologies determine how dendritic trees integrate thousands of synaptic inputs to generate different firing properties. The nervous system is populated by diverse types of neurons, each of which has dendritic trees with strikingly different morphologies.
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